9th European Conference on Mathematical and Theoretical Biology in Gothenburg, June 15-19, 2014
Minisymposium "Mathematical Multiscale Modeling of Cancer Cell Migration"
Christian Stinner & Christina Surulescu (University of Kaiserslautern, Germany)
Invasion of tumor cells is an important component in cancer development. Tumor cells migrate through the surrounding tissue (normal cells, extracellular matrix, interstitial fluid) towards blood or lymph vessels which they penetrate and thus access the blood flow. They are carried by blood circulation to distant locations where they extravasate and develop metastases. The invasive spread of cancer cells is highly complex, as it relies on a plethora of processes taking place on different scales which range from the subcellular level (microscale) through the mesoscopic level of individual cells and up to the macroscale of a cell population. The latter involves phenomena like diffusion, chemotaxis or haptotaxis, separately or in a conjugate way.
The mathematical modeling of these features leads to multiscale settings interconnecting two or all three of these scales and allowing to assess the effects of subcellular events on the behavior of an entire cell population.
Monday, June 16, 2014 (room Ascom)
16:00 - 16:35: Svetlana Bunimovich (Ariel University)
Modeling and simulation of low grade urinary bladder carcinoma (abstract)
16:35 - 17:10: Niklas Kolbe (University of Mainz)
Numerical treatment of chemotaxis related heterogeneous dynamics arising in
cancer invasion simulations (abstract)
17:10 - 17:25: Break
17:25 - 18:00: Cristian Morales Rodrigo (University of Sevilla)
Mathematical models of cancer invasion of tissue: local and nonlocal interactions (abstract)
18:00 - 18:35: Christian Stinner (University of Kaiserslautern)
On a multiscale model involving cell contractivity and its effects on tumor invasion (abstract)